Perfusion Analysis

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The perfusion module can be used to obtain qualitative as well as (semi-) quantitative perfusion maps based on the dynamic (first-pass) effect of a contrast agent (CA). The perfusion module assumes that the input data describes a well-defined and transient signal response following rapid administration of a contrast agent. Analysis can be performed using a variety of different techniques. In particular, the following features are included:

         Perfusion analysis of both positive and negative first-pass effects:

    • Positive first-pass effect describes the situation where the CA causes a transient increase in the signal intensity in the image. This is the case in CT-perfusion and T1-weighted perfusion in MRI (also referred to as dynamic contrast enhanced (DCE) imaging). 
    • Negative first-pass effect describes the situation where the CA leads to a transient decrease in the signal intensity. This is the case in T2- or T2*-weighted MR perfusion imaging. In negative perfusion analysis, the signal change is first converted to relative CA concentration and the resulting concentration time-curve is used for further analysis. This mode of analysis is commonly referred to as dynamic susceptibility contrast (DSC) imaging.

         Optional correction for measured arterial input function (AIF) (deconvolution) using different state-of-the-art deconvolution techniques. 

  • Manual or automatic detection of AIF.
  • Correction for contrast agent leakage to extravascular space through the estimation of a leakage parameter (Ktrans)

 

Subtopics in this section


Perfusion analysis: step by step  

Starting the perfusion analysis
Perfusion Settings

Advanced Perfusion Settings

 



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